How to take vitamin D3 and K2: take them together, once a day, close to a meal, at the same time every day. Both are fat-soluble, so the meal next to them matters more than the clock. For Vitamin K2/D3+, the label says one capsule daily, preferably 20-30 minutes before a meal. Below is a simple serving guide: when to take it, what to eat with it, how to count your vitamin D, and who should check with a provider first.
Vitamin D3 and K2 are a natural pair. D3 promotes calcium absorption, and K2 supports healthy arteries and helps guide that calcium toward the bones.* Because they work as a team, many people take them in one capsule. Getting the routine right is mostly about consistency and a few practical details.
Key takeaways
- Vitamin D3 and K2 are both fat-soluble, so the meal next to them matters more than the clock.
- The Vitamin K2/D3+ label says one capsule daily, preferably 20-30 minutes before a meal.
- Count the vitamin D from every product you take, not just one bottle.
- If you take a blood thinner such as warfarin, talk with your healthcare provider before taking vitamin K2.
What is in Vitamin K2/D3+?
One veggie capsule is the full serving. It contains:
- Vitamin D3 (cholecalciferol): 125 mcg, which is 5,000 IU.
- Vitamin K2 as MK-7 (menaquinone): 100 mcg.
- Calcium (as calcium carbonate): 210 mg.
- BioPerine® black pepper extract: 5 mg, to support absorption.*
Every active is listed with its own amount; there is no proprietary blend. The bottle holds 60 capsules, and at one capsule a day that is a 60-day supply. Vitamin K2/D3+ supports bone health, immune system health, and healthy muscle and nerve function.*
How to take vitamin D3 and K2, step by step
- Pick one meal you eat every day. Breakfast or lunch works for most people.
- Take one capsule 20-30 minutes before that meal with a glass of water, as the label suggests.
- Make it a meal with some fat, such as eggs, yogurt, nuts, avocado, olive oil or fish.
- Keep the time the same from day to day, so the habit sticks.
- Do not double up if you miss a day. Just take the next capsule as usual.
Why the meal matters
Vitamin D3 and K2 are both fat-soluble, so the meal next to them matters more than the clock. Fat-soluble vitamins are absorbed along with the fat in food. Studies of vitamin D3 have found higher blood levels when the dose was taken with a meal that contained fat than with a fat-free meal. Taking the capsule shortly before a meal keeps it close to that food.
You do not need a large or rich meal. A breakfast with eggs or yogurt, or a lunch with olive oil, nuts or fish, is plenty.
Morning or night?
There is no strong evidence that one time of day is better. Most people choose the morning or midday because it is easy to tie to breakfast or lunch, and some prefer to keep vitamin D away from bedtime. The real rule is the one above: same meal, same time, every day.
| Routine | When to take the capsule | Good meal pairing |
|---|---|---|
| Early riser | 20-30 minutes before breakfast | Eggs, Greek yogurt, nut butter on toast |
| Skips breakfast | 20-30 minutes before lunch | Salad with olive oil, salmon, avocado |
| Shift work | Before your first main meal | Any meal with some fat |
Count all of your vitamin D
Count the vitamin D from every product you take, not just one bottle. One capsule of Vitamin K2/D3+ gives 125 mcg (5,000 IU) of vitamin D3. That is above the 100 mcg (4,000 IU) daily upper limit set for adults by the NIH Office of Dietary Supplements. Some people take this amount on a healthcare provider's advice, often after a blood test. If you already take vitamin D from another supplement, or you are not sure how much is right for you, check with your healthcare provider before use.
Many people pair it with Daily Essential+™ and Collagen Complex+ as a daily foundation. A multivitamin usually contains some vitamin D too, so include it in your total. Our guide to how much vitamin D you need per day explains the reference amounts and the upper limit in plain terms.
Can you take vitamin D3 and K2 with other supplements?
- Multivitamin: fine for most people; add up the vitamin D, as above.
- Calcium supplements: Vitamin K2/D3+ already contains some calcium. If you take a separate calcium product, ask your provider what total suits you, since food is the main source.
- Magnesium and omega-3: commonly taken in the same routine.
- Medication: always check with your healthcare provider or pharmacist.
Who should talk with a provider first
If you take a blood thinner such as warfarin, talk with your healthcare provider before taking vitamin K2. Vitamin K can affect how blood-thinning medication works, and steady, predictable intake matters. If you are pregnant, nursing, under 18 or managing a medical condition, check with your provider first as well. Do not exceed the recommended dose.
Every batch of Vitamin K2/D3+ is third-party tested for purity and potency, and it is manufactured in USA with globally sourced materials in an NSF-certified, GMP-certified, FDA-registered facility. See Our Standards for how we test.
Frequently asked questions about how to take vitamin D3 and K2
Should vitamin D3 and K2 be taken together?
Many people take them together because they work as a pair: D3 promotes calcium absorption, and K2 helps guide calcium toward the bones.* Our article Why Vitamin K2 and D3 Work Better Together explains the calcium connection.
Can I take vitamin D3 and K2 on an empty stomach?
Both are fat-soluble, so they are best taken close to a meal that contains some fat. The Vitamin K2/D3+ label suggests taking the capsule 20-30 minutes before a meal.
What happens if I miss a dose?
Take your next capsule at the usual time. Do not take two to make up for a missed one.
How long does a bottle of Vitamin K2/D3+ last?
The bottle holds 60 capsules. At one capsule a day, that is a 60-day supply.
Is 5,000 IU of vitamin D too much?
It is above the 4,000 IU adult upper limit listed by the NIH. Some people take it under a provider's guidance. If you are not sure it is right for you, talk with your healthcare provider before use.
Related reading from our Wellness Hub
- Why Vitamin K2 and D3 Work Better Together: The Calcium Connection
- How Much Vitamin D Do You Need Per Day? A Clear Guide
- How to Keep Bones Strong
Sources
- NIH Office of Dietary Supplements: Vitamin D Fact Sheet for Health Professionals
- NIH Office of Dietary Supplements: Vitamin K Fact Sheet for Health Professionals
- Dawson-Hughes B, et al. Dietary fat increases vitamin D-3 absorption. Journal of the Academy of Nutrition and Dietetics, 2015 (PubMed)
- NIH Office of Dietary Supplements: Calcium Fact Sheet for Health Professionals
Individual results vary.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
